# CJC-1295 References: The Cited Research Record

> The full CJC-1295 reference list: the human pharmacokinetic studies, the albumin-bioconjugate and GHRH-knockout-mouse work, the analytical and anti-doping methods, and the recent reviews — with DOIs and PubMed links.

Every figure on this site maps to one of these studies. The human pharmacokinetic record, the preclinical mechanism work, and the analytical literature, each with a DOI or PubMed link.

## How to Read This List

These are the CJC-1295 references behind every quantitative claim on this site. The list separates into three groups: the early human pharmacokinetic studies that established the GH/IGF-1 kinetics and the DAC half-life [1][3][5], the preclinical work that identified the bioconjugate and demonstrated once-daily growth normalization [2][4], and the analytical and anti-doping literature plus recent reviews that document the compound's detection science and its place in the GHRH-analog class [6][7][8][9][10][11][12][13][14][15].

Where a study is paywalled, the PubMed abstract and DOI remain freely resolvable. The full citations follow in the references list below.

## References

[1] Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006;91(3):799-805. https://pubmed.ncbi.nlm.nih.gov/16352683/
[2] Jette L, Leger R, Thibaudeau K, Benquet C, Robitaille M, Pellerin I, et al. Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology. 2005;146(7):3052-3058. https://pubmed.ncbi.nlm.nih.gov/15817669/
[3] Ionescu M, Frohman LA. Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. J Clin Endocrinol Metab. 2006;91(12):4792-4797. https://pubmed.ncbi.nlm.nih.gov/17018654/
[4] Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006;291(6):E1290-E1294. https://pubmed.ncbi.nlm.nih.gov/16822960/
[5] Sackmann-Sala L, Ding J, Frohman LA, Kopchick JJ. Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. Growth Horm IGF Res. 2009;19(6):471-477. https://pubmed.ncbi.nlm.nih.gov/19386527/
[6] Henninge J, Pepaj M, Hullstein I, Hemmersbach P. Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation. Drug Test Anal. 2010;2(11-12):647-650. https://pubmed.ncbi.nlm.nih.gov/21204297/
[7] Antibody-free, ultrafiltration-based assay for the detection of growth hormone-releasing hormone analogs. J Pharm Biomed Anal. 2022. https://pubmed.ncbi.nlm.nih.gov/35298973/
[8] Advances in the detection of growth hormone releasing hormone synthetic analogs. Drug Test Anal. 2021. https://pubmed.ncbi.nlm.nih.gov/34665524/
[9] Qualitative identification of growth hormone-releasing hormones in human plasma by means of immunoaffinity purification and LC-MS. Anal Bioanal Chem. 2016. https://pubmed.ncbi.nlm.nih.gov/26879649/
[10] Agonistic analogs of growth hormone releasing hormone (GHRH) promote wound healing. Oncotarget. 2016. https://pubmed.ncbi.nlm.nih.gov/27494841/
[11] GHRH expression plasmid improves osteoporosis and skin damage in aged mice. Growth Horm IGF Res. 2021. https://pubmed.ncbi.nlm.nih.gov/34507253/
[12] Granata R, Leone S, Zhang X, Gesmundo I, et al. Growth hormone-releasing hormone and its analogues in health and disease. Nat Rev Endocrinol. 2025;21(3):180-195. https://pubmed.ncbi.nlm.nih.gov/39537825/
[13] Chromatographic-mass spectrometric analysis of peptidic analytes (2-10 kDa) in doping control. J Mass Spectrom. 2024. https://pubmed.ncbi.nlm.nih.gov/38197510/
[14] Analysis of growth hormone releasing hormone and its analogs in urine using nano-LC-MS. J Pharm Biomed Anal. 2025. https://pubmed.ncbi.nlm.nih.gov/41138283/
[15] Therapeutic peptides in gerontology: mechanisms and applications for healthy aging. Front Aging. 2026. https://pubmed.ncbi.nlm.nih.gov/42021992/

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A layered, lit-from-behind reading of the published CJC-1295 record — the long-acting DAC evidence racked deep, the short-acting no-DAC form held in front, the human-data gaps left clear through the glass, and no clinic, vendor, or prescription anywhere behind it.